Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population

Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role. It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells. It has also been established that deficiency of the Foxp3 gene suppresses the regulatory function of Treg cells. To determine if functional polymorphisms at the Foxp3 loci are associated with URSA in humans, we genotyped four common polymorphisms of Foxp3 gene in 146 unrelated URSA patients and 112 healthy women. The results showed that rs3761548A/C and rs2232365A/G polymorphisms were significantly associated with URSA. Additionally, we found that the allelic distribution of rs5902434 del/ATT in URSA group was slightly different from that in the control group. We conclude that functional polymorphisms of the Foxp3 gene may confer an important susceptibility to URSA in the Chinese Han population, probably by altering Foxp3 function and/or its expression

A Review of Static Pressure Reset Control in Variable Air Volume Air Condition System

AbstractFor the sake of energy saving of variable air volume (VAV) system, this paper presents the a review of static pressure control around the optimization problem of static pressure reset in VAV air conditioning system. Then, main control methods of static pressure reset are described, and existing problems are analyzed and concluded. Finally, it is pointed out that the critical technology and the development trend of static pressure reset control. This overview is not intended to be an exhaustive survey on this topic, and any omission of other works is purely unintentional

Perspective Plane Program Induction from a Single Image

We study the inverse graphics problem of inferring a holistic representation for natural images. Given an input image, our goal is to induce a neuro-symbolic, program-like representation that jointly models camera poses, object locations, and global scene structures. Such high-level, holistic scene representations further facilitate low-level image manipulation tasks such as inpainting. We formulate this problem as jointly finding the camera pose and scene structure that best describe the input image. The benefits of such joint inference are two-fold: scene regularity serves as a new cue for perspective correction, and in turn, correct perspective correction leads to a simplified scene structure, similar to how the correct shape leads to the most regular texture in shape from texture. Our proposed framework, Perspective Plane Program Induction (P3I), combines search-based and gradient-based algorithms to efficiently solve the problem. P3I outperforms a set of baselines on a collection of Internet images, across tasks including camera pose estimation, global structure inference, and down-stream image manipulation tasks.Comment: CVPR 2020. First two authors contributed equally. Project page: http://p3i.csail.mit.edu

A comprehensive review of acoustic methods for locating underground pipelines

Underground pipelines are vital means of transporting fluid resources like water, oil and gas. The process of locating buried pipelines of interest is an essential prerequisite for pipeline maintenance and repair. Acoustic pipe localization methods, as effective trenchless detection techniques, have been implemented in locating underground utilities and shown to be very promising in plastic pipeline localization. This paper presents a comprehensive review of current acoustic methods and recent advances in the localization of buried pipelines. Investigations are conducted from multiple perspectives including the wave propagation mechanism in buried pipe systems, the principles behind each method along with advantages and limitations, representative acoustic locators in commercial markets, the condition of buried pipes, as well as selection of preferred methods for locating pipelines based on the applicability of existing localization techniques. In addition, the key features of each method are summarized and suggestions for future work are proposed. Acoustic methods for locating underground pipelines have proven to be useful and effective supplements to existing localization techniques. It has been highlighted that the ability of acoustic methods to locate non-metallic objects should be of particular practical value. While this paper focuses on a specific application associated with pipeline localization, many acoustic methods are feasible across a wide range of underground infrastructures